EPA releases endocrine disruptor screening results for pesticides

The Food Quality Protection Act directed the Environmental Protection Agency (EPA) to develop a program to screen pesticides and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife.

The EPA endocrine disruptor screening program (EDSP) is a two-tier screening program, with Tier 1 testing designed to identify substances that have potential to interact with estrogen, androgen, or thyroid hormone systems. Those substances are then subject to additional review by EPA and possible referral to Tier 2 testing.

The initial set of chemicals subject to Tier 1 testing were all pesticides, three of which, 2,4-D, atrazine, and glyphosate, are herbicides used in forestry. On June 30, EPA released its reviews of the Tier 1 screening assay results. For glyphosate, EPA reported that “there was no convincing evidence of potential interaction with the estrogen, androgen, or thyroid pathways,” and it did not recommend mammalian or wildlife Tier 2 testing. For 2,4-D, EPA concluded that additional Tier 2 ecological testing was not required and noted that the agency already had results from a mammalian toxicity study that is equivalent to the EDSP Tier 2 study for mammals. EPA likewise did not recommend EDSP Tier 2 testing of any kind for atrazine, although the rationale in this case was that “it is not expected to impact current EPA-established regulatory endpoints for human health or ecological risk assessment.”

Additional information on the results of Tier 1 testing may be found on the EPA website at http://www2.epa.gov/ingredients-used-pesticide-products/endocrine-disruptor-screening-program-tier-1-assessments.

This page also provides a list of pesticides for which EPA has released Tier 1 results with links to the full reviews.


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